Ariff bongso biography of michael

But in the wake of that early euphoria, the stem cell industry at large was about to experience its first boom and bust cycle. ByESI had given up its research on treatments for diabetes and heart failure, switching instead to the less risky option of licensing hESC lines and using them in screening assays for drug development. Pressing on.

Ariff bongso biography of michael: Ariff Bongso and; Eng

Professor Bongso has continued slowly chipping away at the hurdles in stem cell research. As excited as Professor Bongso is about his current research, he has not neglected to train the next generation of scientists. Fong Chui Yee, for instance, was once his student and is now a respected researcher in her own right. She has worked closely with Professor Bongso over the years and is poised to take over his lab when he retires.

Click here to read the rest of the articles in this series. Disclaimer: This article does not necessarily reflect the views of AsianScientist or its staff. Rebecca did her PhD at the National University of Singapore where she studied how macrophages integrate multiple signals from the toll-like receptor system. She was formerly the editor-in-chief of Asian Scientist Magazine.

Asia is going through a sleep crisis, worse than anywhere else in the world, leading to a growth in the market of sleep wearables.

Ariff bongso biography of michael: Professor Ariff Bongso · A/Prof

But how much do they help? August 28, Features By Rebecca Tan. Conceiving Many World Firsts. Reaching peak productivity in Singapore Like many other IVF pioneers in his time, Professor Bongso, a native of Sri Lanka, first perfected his skills on animal embryos before making the jump to humans. However, culturing hESCs on mouse feeder cells is not without its limitations.

Riding the wave But the problem of mouse feeder cells was only one of many. Thus, my research has not been affected because I know where my boundaries lie. I see little interest in this important area as safety is fundamental to taking this science to the clinic. It has been claimed that even a few rogue undifferentiated hESCs in the hESC-derived tissue population can induce teratomas in immunodeficient mice.

Ariff bongso biography of michael: In , Professor Ariff Bongso, who

This thus is a very worrying problem. Once this issue is resolved I believe that the nearest application of hESC research should be for liver diseases cirrhosis and liver failure. It has its own stem cells, is not a complicated organ like the brain or heart. Injecting just a few hESC-derived hepatocytes may help to trigger of the intrinsic regeneration process in patients with cirrhosis still having a part of intact liver.

We can also learn a lot from the regenerative machinery of this organ. Although nice in vitro systems that can help promote differentiation of hESC or iPSCs towards a germ cell lineage have been developed, there would be obstacles at the point of meiosis to produce complete functional gametes for the purpose of human infertility. The molecular mechanisms involved during and after meiosis in vitro, are very complex and would require very complex in vitro environments.

SCP: Are there ways in which you feel we should be educating and including the public in this important work? AB: I believe this is very important. I have been personally involved with the Singapore public, giving talks, seminars and discussions using powerpoint slide presentations. These were also delivered to religious organizations.

The transcriptome profile of human embryonic stem cells as defined by SAGE. Stem Cells, 22, : Bongso A and S. Tan, Human blastocyst culture and derivation of embryonic stem cell lines. Stem Cell Reviews, 1: : Bongso, The search for factors in human feeders that support the derivation and propagation of human embryonic stem cells: preliminary studies using transcriptome filing by SAGE.

Fertil and Steril 85 : Bongso, Reverse SAGE characterization of orphan SAGE tags from human embryonic stem cells identifies the presence of novel transcripts and antisense transcription of key pluripotency genes. Stem Cells, : Bongso, Unsuccessful derivation of human embryonic stem cell lines from pairs of human blastomeres.

Ariff bongso biography of michael: Arif Bongso, gynecologist in Singapore,

The Open Biotechnology Journal, 2: Journal of Cellular Biochemistry, Richards M, Fong CY, Bongso A Comparative evaluation of different in vitro systems that stimulate germ cell differentiation in human embryonic stem cells. Fertility and Sterility In Press: doi British J of Pharmacology In Press. J Cellular and Mol Med. In Press J Cellular Biochem.